Basic Identification

Chemical Name

1,2-Benzisothiazolin-3-one

Abbreviation

BIT

CAS Registry Number

2634-33-5

EINECS Number

220-120-9

Molecular Formula

C₇H₅NOS

Molecular Weight

151.19 g/mol

Physicochemical Properties

Appearance

White to pale yellow crystalline powder

Melting Point

155–158 °C

Water Solubility

~0.14% at 25 °C; 1.5% at 90 °C

pH Value (10% Aqueous Solution)

9.0–11.0

Thermal Stability

Stable below 180 °C

Solubility in Organic Solvents

Soluble in polar organic solvents (e.g., alcohols, ketones); slightly soluble in non-polar solvents

Biological Activity

Antimicrobial Spectrum

Broad-spectrum (effective against bacteria, fungi, and algae)

Mechanism of Action

Inhibits microbial enzyme activity by binding to -SH groups of intracellular proteins

Typical Dosage Range

0.05%–0.5% (by mass, depending on application scenarios)

Industrial Formulations

Common Commercial Grades

BIT-20 (20% BIT in ethylene glycol aqueous solution); BIT-10 (10% BIT formulation)

Formulation Feature

Easy to disperse, long-term preservative effect, stable under alkaline conditions

Safety & Environmental Indicators

Skin Irritation

Irritating to skin and eyes; requires protective equipment during operation

Sensitization Risk

May cause skin sensitization with prolonged contact

Biodegradability

Biodegradable in natural environment with no persistent residues

Aquatic Toxicity

Highly toxic to aquatic organisms; avoid release into water bodies