Detalles esenciales
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Introducción del producto
| Parameter Category | Parameter Name | English Value/Specification |
|---|---|---|
| Basic Identification | Chemical Name | Zinc bis(1-hydroxy-2(1H)-pyridinethione); Zinc pyrithione; Bis(pyridin-2-ylthio)zinc |
| Abbreviation/INCI Name | ZPT; Zinc Pyrithione (INCI); Pyrithione Zinc | |
| CAS Registry Number | 13463-41-7 | |
| EINECS/EC Number | 236-671-3 | |
| Molecular Formula | C₁₀H₈N₂O₂S₂Zn | |
| Molecular Weight | 317.68 g/mol | |
| Chemical Class | Pyridinethione metal complex; antifungal agent; anti-dandruff active; industrial biocide | |
| Physicochemical Properties | Appearance | Pale yellow to off-white crystalline powder; odorless or with faint characteristic odor |
| Melting Point | 240–245 °C (decomposes above melting point, releasing pyrithione) | |
| Boiling Point | Decomposes prior to reaching boiling temperature (no defined boiling point) | |
| Density (20 °C) | 1.78 g/cm³ (crystalline form) | |
| Water Solubility (25 °C) | Poorly soluble (~0.001 g/100 mL, pH 7); solubility increases in acidic/alkaline aqueous systems (up to 0.1 g/100 mL at pH <4 or pH >9) | |
| Organic Solvent Solubility | Slightly soluble in ethanol, propylene glycol; insoluble in non-polar solvents (hexane, mineral oil); soluble in dimethyl sulfoxide (DMSO) | |
| pH Value (1% Aqueous Suspension) | 6.0–7.5 (neutral range, no significant pH impact on formulations) | |
| LogP (Octanol-Water Partition Coefficient) | 1.5–1.8 (moderate hydrophilicity, suitable for scalp/hair deposition) | |
| Stability | Stable at pH 5.0–8.0 (optimal for cosmetics); sensitive to strong UV light (degrades, turns brown); stable under cool/dry conditions | |
| Biological Activity | Core Functions | Anti-dandruff (targets Malassezia spp.); antifungal/antibacterial; sebum-regulating; anti-inflammatory |
| Mechanism of Action | Inhibits fungal membrane ergosterol biosynthesis (binds to zinc-dependent enzymes); disrupts microbial electron transport chain; chelates iron essential for microbial growth | |
| Minimum Inhibitory Concentration (MIC) | Malassezia furfur: 0.1–0.5 ppm; Candida albicans: 0.5–1.0 ppm; Staphylococcus aureus: 1–5 ppm | |
| Effective Concentration Range | 0.5–1.0% (anti-dandruff shampoos/conditioners); 0.2–0.5% (leave-on scalp treatments); 0.1–0.3% (industrial antifungal coatings) |
