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แนะนำผลิตภัณฑ์
| Parameter Category | Parameter Name | English Value/Specification |
|---|---|---|
| Basic Identification | Chemical Name | Octanohydroxamic acid; Caprylohydroxamic acid; Octhilinone |
| Abbreviation/INCI Name | Octhilinone; Caprylohydroxamic Acid (INCI); OHA | |
| CAS Registry Number | 7377-03-9 | |
| EINECS/EC Number | 230-933-9 | |
| Molecular Formula | C₈H₁₇NO₂ | |
| Molecular Weight | 159.22 g/mol | |
| Chemical Class | Aliphatic hydroxamic acid; metal-chelating antimicrobial; non-formaldehyde-releasing preservative | |
| Physicochemical Properties | Appearance | White to off-white crystalline powder; odorless or with a faint fatty acid-like odor |
| Melting Point | 82–86 °C (literature value) | |
| Boiling Point | Decomposes prior to reaching boiling temperature (decomposes at >180 °C, releasing hydroxylamine derivatives) | |
| Density (20 °C) | 1.02 g/cm³ (estimated, crystalline form) | |
| Water Solubility (25 °C) | Slightly soluble (~0.1 g/100 mL); solubility improves in alkaline systems (pH>7) or with cosolvents (propylene glycol/glycerin) | |
| Organic Solvent Solubility | Soluble in ethanol, propylene glycol, glycerin, and cosmetic esters; partially soluble in mineral oil; insoluble in non-polar hydrocarbons | |
| pH Value (1% Aqueous Dispersion) | 5.0–7.0 (neutral range, no pH disruption to formulations) | |
| LogP (Octanol-Water Partition Coefficient) | 2.5–2.8 (balanced lipophilic-hydrophilic property, favorable for skin surface adhesion) | |
| Stability | Stable at pH 4.0–8.0 (optimal for cosmetic systems); heat-stable (up to 80 °C for short-term processing); light-stable; non-hygroscopic | |
| Biological Activity | Core Functions | Broad-spectrum antimicrobial (fungi > bacteria); metal ion chelator (Fe³+/Cu²+); preservative synergist; mild skin conditioner |
| Mechanism of Action | Chelates transition metal ions (Fe³+/Cu²+) essential for microbial enzyme activity; disrupts fungal cell wall biosynthesis; enhances efficacy of co-preservatives | |
| Minimum Inhibitory Concentration (MIC) | Aspergillus niger: 0.1–0.5 ppm; Candida albicans: 0.2–0.8 ppm; Staphylococcus aureus: 1.0–2.0 ppm | |
| Effective Concentration Range | 0.1–0.5% (cosmetic/personal care products); 0.2–1.0% (industrial coatings/ adhesives); 0.05–0.2% (synergistic use with phenoxyethanol/EHG) |
