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| Parameter Category | Parameter Name | English Value/Specification |
|---|---|---|
| Basic Identification | Chemical Name | 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolamine salt (monoethanolamine salt of piroctone) |
| Abbreviation/INCI Name | Piroctone Olamine; PO; Octopirox®; CS-7659 | |
| CAS Registry Number | 68890-66-4 | |
| EINECS/EC Number | 272-574-2 | |
| Molecular Formula | C₁₆H₃₀N₂O₃ (or C₁₄H₂₃NO₂·C₂H₇NO) | |
| Molecular Weight | 298.42 g/mol | |
| Chemical Class | Hydroxypyridone-derived antifungal agent; antimycotic cosmeceutical ingredient | |
| UNII Number | A4V5C6R9FB | |
| Physicochemical Properties | Appearance | White or slightly yellow crystalline powder; odorless or with faint distinctive odor |
| Melting Point | 130–135 °C (literature value) | |
| Boiling Point | Decomposes prior to reaching boiling temperature | |
| Density (20 °C) | 1.10 g/cm³ (estimated) | |
| Water Solubility (25 °C) | Slightly soluble (approximately 0.5% w/w in aqueous systems) | |
| Organic Solvent Solubility | Soluble in ethanol, propylene glycol, glycerin, and acetone; poorly soluble in non-polar solvents | |
| pH Value (1% Aqueous Solution) | 8.0–9.0 (slightly alkaline) | |
| LogP (Octanol-Water Partition Coefficient) | 3.2–3.5 (moderate lipophilicity, favorable for skin/scalp penetration) | |
| Stability | Stable under normal storage conditions; light-stable; compatible with most cosmetic ingredients | |
| Biological Activity | Antimicrobial Spectrum | Broad-spectrum (effective against Malassezia species, Candida albicans, Trichophyton spp., and some Gram-positive bacteria) |
| Minimum Inhibitory Concentration (MIC) | Malassezia furfur: 0.1–0.5 μg/mL; Candida albicans: 1–5 μg/mL; Trichophyton rubrum: 0.5–2 μg/mL | |
| Mechanism of Action | Chelates iron ions essential for fungal enzymes, disrupts mitochondrial energy metabolism, and inhibits fungal cell growth |
